EFNA1 Recombinant Protein
Produktgrößen
100ug
£760,00
OPCA00074-100UG
1mg
£2912,00
OPCA00074-1MG
Über dieses Produkt
- SKU:
- OPCA00074
- Zusätzliche Namen:
- B61;EPH-related receptor tyrosine kinase ligand 1;ephrin-A1;immediate early response protein B61;LERK-1.
- Weitere Details:
- Cell surface GPI-bound ligand for Eph receptors; a family of receptor tyrosine kinases which are crucial for migration; repulsion and adhesion during neuronal; vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells; leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2; VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
- Gendetails:
- ephrin A1
- Molekulargewicht:
- 46.4 kDa
- Proteindetails:
- Ephrin-A1
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php