AXIN1 ELISA Kit
Produktgrößen
96T
£788,00
OKEH04969-96T
Über dieses Produkt
- SKU:
- OKEH04969
- Zusätzliche Namen:
- Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800
- Weitere Details:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination; and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos; but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling; probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth; apoptosis and development.
- Gendetails:
- Axin 1
- Proteindetails:
- Axin-1
- Empfindlichkeit:
- 39.8 pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs