Angiotensin I ELISA Kit
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96 Wells
£897,00
OKEH02621-96WELLS
Über dieses Produkt
- SKU:
- OKEH02621
- Zusätzliche Namen:
- Ang-I; Angiotensin I; Ang-I
- Weitere Details:
- Angiotensins are small peptides derived from angiotensinogen. Several of the known Angiotensins are established endocrine effectors in the regulation of blood pressure; but they are also known to have other functions locally; in several organs and tissues (paracrine) and at the cellular level (autocrine / intracrine). Angiotensin I has no known effector function but it is an immediate precursor of Angiotensin II. Angiotensin II binds AT1 receptors; which promote vasoconstriction; sodium retention; release of aldosterone; release of Argâ€Âvasopressin; cell proliferation; inflammation; fibrosis; anxiety; and cardiac hypertrophy. Angiotensin A and Angiotensin III; also bind AT1 receptors. Angiotensin (1â€Â7) binds a different receptor called MASâ€Â1 which has opposite effects (vasodilation; natriuresis; antiproliferation; NO release; PGE release; and apoptosis). Angiotensin IV binds yet another receptor called AT4 (IRAP); which promotes increase of blood flow; angiogenesis; and natriuresis; and which has also been implicated in memory formation and in the pathogenesis of Alzheimer’s disease. The peptide LVVâ€Âhemorphinâ€Â7; which is not an angiotensin; also binds the AT4 receptor. There are other angiotensin peptides that Discover more at www.abcam.com 3 INTRODUCTION have been identified; including Ang (1â€Â9); Ang (1â€Â12); Ang V(3â€Â7); as well as several other shorter peptides that have undetermined functions. Angiotensins can be present in very low concentrations in some biological samples. In such cases; dilution of samples to avoid “nonâ€Âspecific†interference by any present factors is not productive because the angiotensin analyte is also diluted to levels far below the minimum detection concentration. Thus; investigators have used several procedures for extracting Angiotensins from biological samples prior to using them for immunoassays. Angiotensins share common sequences; and in some cases they cannot be discriminated by immunoassays. Prior extraction and separation by HPLC may; thus; be required.
- Proteindetails:
- Angiotensin I
- Empfindlichkeit:
- 22 pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs