2; 3-Bisphosphoglycerate ELISA Kit
Produktgrößen
96 Wells
£788,00
OKEH02577-96WELLS
Über dieses Produkt
- SKU:
- OKEH02577
- Zusätzliche Namen:
- 2; 3-BPG; 2; 3-Bisphosphoglycerate; 2; 3-BPG; 2; 3-Bisphosphoglyceric acid; 2; 3-diphosphoglycerate
- Weitere Details:
- 2;3-Bisphosphoglyceric acid (2;3-Bisphosphoglycerate or 2;3-BPG; also known as 2;3-diphosphoglycerate or 2;3-DPG) is a three-carbon isomer of the glycolytic intermediate 1;3-bisphosphoglyceric acid (1;3-BPG). 2;3-BPG is present in human red blood cells (RBC; erythrocyte) at approximately 5 mmol/L. It binds with greater affinity to deoxygenated hemoglobin (e.g. when the red cell is near respiring tissue) than it does to oxygenated hemoglobin (e.g.; in the lungs) due to spatial changes: 2;3-BPG (whose size is estimated at about 9 angstroms) fits in the deoxygenated hemoglobin configuration (11 angstroms); but not as well in the oxygenated (5 angstroms). It interacts with deoxygenated hemoglobin beta subunits by decreasing their affinity for oxygen; so it allosterically promotes the release of the remaining oxygen molecules bound to the hemoglobin; thus enhancing the ability of RBCs to release oxygen near tissues that need it most. 2;3-BPG is thus an allosteric effector.
- Proteindetails:
- 2; 3-Bisphosphoglycerate
- Empfindlichkeit:
- 9.7nmol/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs