FGFR3 ELISA Kit
Produktgrößen
96T
£868,00
OKDD00794-96T
Über dieses Produkt
- SKU:
- OKDD00794
- Zusätzliche Namen:
- CD333;Fgfr-;Fgfr-3;fibroblast growth factor receptor 3;Flg-2;FR3;HBGF;HBGFR;heparin-binding growth factor receptor;Mfr3;sa;sam3.
- Weitere Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation; differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation; proliferation and apoptosis; and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes; but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1; CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation; internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1; STAT5A and STAT5B. Plays a role in postnatal lung development.
- Gendetails:
- fibroblast growth factor receptor 3
- Molekulargewicht:
- 88 kDa
- Proteindetails:
- Fibroblast growth factor receptor 3
- Empfindlichkeit:
- <0.057ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php