CFTR ELISA Kit
Produktgrößen
96T
£1016,00
OKDD00186-96T
Über dieses Produkt
- SKU:
- OKDD00186
- Zusätzliche Namen:
- ABC35;ABCC7;ATP-binding cassette sub-family C member 7;cAMP-dependent chloride channel;CF;CFTR/MRP;channel conductance-controlling ATPase;cystic fibrosis transmembrane conductance regulating;cystic fibrosis transmembrane conductance regulator;cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C; member 7);dJ760C5.1;MRP7;TNR-CFTR.
- Weitere Details:
- Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060; PubMed:11524016; PubMed:11707463; PubMed:12519745; PubMed:15010471; PubMed:12588899; PubMed:17036051; PubMed:19398555; PubMed:19621064; PubMed:22178883; PubMed:25330774; PubMed:1712898; PubMed:8910473; PubMed:9804160; PubMed:12529365; PubMed:17182731; PubMed:26846474; PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471; PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779; PubMed:22178883; PubMed:22121115; PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176; PubMed:19621064; PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433; PubMed:16645176; PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex; in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346; PubMed:27941075; PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A; SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D; SCNN1B and SCNN1G; but not of the ENaC channel containing subunits SCNN1A; SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167; PubMed:27714810).
- Gendetails:
- CF transmembrane conductance regulator
- Molekulargewicht:
- 168 kDa
- Proteindetails:
- Cystic fibrosis transmembrane conductance regulator
- Empfindlichkeit:
- < 0.053 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php