ATF4 ELISA Kit
Produktgrößen
96T
£955,00
OKDD00138-96T
Über dieses Produkt
- SKU:
- OKDD00138
- Zusätzliche Namen:
- Activating transcription factor 4;cAMP response element-binding protein 2;cAMP-dependent transcription factor ATF-4;cAMP-responsive element-binding protein 2;CREB2;CREB-2;cyclic AMP-dependent transcription factor ATF-4;cyclic AMP-responsive element-binding protein 2;DNA-binding protein TAXREB67;TAXREB67;tax-responsive enhancer element B67;tax-responsive enhancer element-binding protein 67;TXREB.
- Weitere Details:
- Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'); a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP; activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response; activates the transcription of NLRP1; possibly in concert with other factors (PubMed:26086088).
- Gendetails:
- activating transcription factor 4
- Molekulargewicht:
- 39 kDa
- Proteindetails:
- Cyclic AMP-dependent transcription factor ATF-4
- Empfindlichkeit:
- < 0.057 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php