DNASE1L3 ELISA Kit
Produktgrößen
96 Wells
£955,00
OKCD09306-96WELLS
Über dieses Produkt
- SKU:
- OKCD09306
- Zusätzliche Namen:
- deoxyribonuclease gamma;deoxyribonuclease I-like 3;Dhp2;DNase;DNase gamma;DNase I homolog protein DHP2;DNase I-like 3;DNasegamma;liver and spleen DNase;Lsd;LS-DNase;macrophage specific DNase I.
- Weitere Details:
- Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage; producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:15796714; PubMed:19154352; PubMed:12095301). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation; and BCR-mediated clonal deletion of self-reactive B cells (PubMed:12050166; PubMed:15167901; PubMed:17218958; PubMed:24312463). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:15796714; PubMed:27293190). Together with DNASE1; plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910).
- Gendetails:
- deoxyribonuclease 1-like 3
- Proteindetails:
- Deoxyribonuclease gamma
- Empfindlichkeit:
- < 0.054ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php