CD5L ELISA Kit
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96 Wells
£955,00
OKCD09297-96WELLS
Über dieses Produkt
- SKU:
- OKCD09297
- Zusätzliche Namen:
- 1/6;A;AAC-;AAC-11;AI047839;AIM;AIM/Spalpha;Api6;apoptosis inhibitor 6;apoptosis inhibitor expressed by macrophages;Apoptosis inhibitory 6;CD5 antigen-like;CT2;CT-2;mAIM;Pdp;Pdp 1/6;Sp;Sp-alpha.
- Weitere Details:
- Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses; such as infection or atherosclerosis (PubMed:26048980). Able to inhibit lipid droplet size in adipocytes (PubMed:20519120; PubMed:22579686). Following incorporation into mature adipocytes via CD36-mediated endocytosis; associates with cytosolic FASN; inhibiting fatty acid synthase activity and leading to lipolysis; the degradation of triacylglycerols into glycerol and free fatty acids (FFA) (PubMed:20519120). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues; a cause of insulin resistance and obesity-related metabolic disease (PubMed:21730133). Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC) (PubMed:22579686; PubMed:26607793). Acts as a key regulator of metabolic switch in T-helper Th17 cells (PubMed:26607794; PubMed:26607793). Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC; the master transcription factor of Th17-cell differentiation (PubMed:26607793). CD5L is mainly present in non-pathogenic Th17 cells; where it decreases the content of polyunsaturated fatty acyls (PUFA); affecting two metabolic proteins MSMO1 and CYP51A1; which synthesize ligands of RORC; limiting RORC activity and expression of pro-inflammatory genes (PubMed:26607793). Participates in obesity-associated autoimmunity via its association with IgM; interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (PubMed:23562157). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:9892623; PubMed:16054063). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (By similarity).
- Gendetails:
- CD5 antigen-like
- Proteindetails:
- CD5 antigen-like
- Empfindlichkeit:
- < 0.136ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php