AXL ELISA Kit
Produktgrößen
96 Wells
£955,00
OKCD09290-96WELLS
Über dieses Produkt
- SKU:
- OKCD09290
- Zusätzliche Namen:
- ARK;AXL oncogene;AXL transforming sequence/gene;JTK11;Tyro7;tyrosine-protein kinase receptor UFO;UFO.
- Weitere Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival; cell proliferation; migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand; ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1; PIK3R2 and PIK3R3; but also GRB2; PLCG1; LCK and PTPN11. Other downstream substrate candidates for AXL are CBL; NCK2; SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
- Gendetails:
- AXL receptor tyrosine kinase
- Proteindetails:
- Tyrosine-protein kinase receptor UFO
- Empfindlichkeit:
- < 0.112ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php