GNAI3 ELISA Kit
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96 Wells
£1016,00
OKCD09135-96WELLS
Über dieses Produkt
- SKU:
- OKCD09135
- Zusätzliche Namen:
- 87U6;ARCND1;g(i) alpha-3;guanine nucleotide binding protein (G protein); alpha inhibiting activity polypeptide 3;guanine nucleotide-binding protein G(i) subunit alpha;guanine nucleotide-binding protein G(i) subunit alpha-3;guanine nucleotide-binding protein G(k) subunit alpha.
- Weitere Details:
- Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active; GTP-bound state and an inactive; GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP; thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883; PubMed:18434541; PubMed:19478087). Signaling is mediated via effector proteins; such as adenylate cyclase. Inhibits adenylate cyclase activity; leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).
- Gendetails:
- G protein subunit alpha i3
- Proteindetails:
- Guanine nucleotide-binding protein G(k) subunit alpha
- Empfindlichkeit:
- < 0.062ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php