CRBN ELISA Kit
Produktgrößen
96 Wells
£1016,00
OKCD08967-96WELLS
Über dieses Produkt
- SKU:
- OKCD08967
- Zusätzliche Namen:
- MRT2;MRT2A;protein cereblon;protein x 0001.
- Weitere Details:
- Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein; leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC; IRF4; IKZF1 and IKZF3.
- Gendetails:
- cereblon
- Proteindetails:
- Protein cereblon
- Empfindlichkeit:
- < 0.057ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php