CLU ELISA Kit
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96 Wells
£673,00
OKCD07188-96WELLS
Über dieses Produkt
- SKU:
- OKCD07188
- Zusätzliche Namen:
- AAG4;Aging-associated gene 4 protein;aging-associated protein 4;APOJ;APO-J;apolipoprotein J;CLI;CLU1;CLU2;clusterin;complement cytolysis inhibitor;complement lysis inhibitor;complement-associated protein SP-40;40;epididymis secretory sperm binding protein;ku70-binding protein 1;KUB1;NA1/NA2;SGP2;SGP-2;SP-40;sulfated glycoprotein 2;testosterone-repressed prostate message 2;TRPM2;TRPM-2.
- Weitere Details:
- Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP; APOC2; B2M; CALCA; CSN3; SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones; such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
- Gendetails:
- clusterin
- Proteindetails:
- Clusterin
- Empfindlichkeit:
- < 5.1ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php