AIFM1 ELISA Kit
Produktgrößen
96 Wells
£1042,00
OKCD07109-96WELLS
Über dieses Produkt
- SKU:
- OKCD07109
- Zusätzliche Namen:
- Aif;apoptosis-inducing factor 1; mitochondrial;apoptosis-inducing factor 1; mitochondrial-like;apoptosis-inducing factor; mitochondrion-associated 1;Pdcd8;programmed cell death 8 (apoptosis-inducing factor);programmed cell death protein 8.
- Weitere Details:
- Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli; it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus; where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast; functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G;and thereby inhibits the EIF3 machinery and protein synthesis;and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent; pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).
- Gendetails:
- apoptosis inducing factor; mitochondria associated 1
- Proteindetails:
- Apoptosis-inducing factor 1; mitochondrial
- Empfindlichkeit:
- < 0.061ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php