ESR1 ELISA Kit
Produktgrößen
96 Wells
£1042,00
OKCD07097-96WELLS
Über dieses Produkt
- SKU:
- OKCD07097
- Zusätzliche Namen:
- C-terminally-truncated estrogen receptor alpha product-1;Er alpha;ER-alpha;Esr;estradiol receptor;estrogen receptor;estrogen receptor 1 (alpha);estrogen receptor alpha c-terminus splice variant 1-2;estrogen receptor alpha i45aL;estrogen receptor alpha i45aS;estrogen receptor alpha i45c;estrogen receptor alpha i56a;estrogen receptor alpha i56b;estrogen receptor alpha i56c;estrogen receptor alpha i56dL;estrogen receptor alpha i56dS;estrogen receptor alpha i56e;estrogen receptor alpha variant delta 4;estrogen receptor protein;nuclear receptor subfamily 3 group A member 1;RNESTROR;truncated estrogen receptor product-2;trunctaed estrogen receptor product-1.
- Weitere Details:
- Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors; such as AP-1/c-Jun; c-Fos; ATF-2; Sp1 and Sp3; to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
- Gendetails:
- estrogen receptor 1
- Proteindetails:
- Estrogen receptor
- Empfindlichkeit:
- < 0.126ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php