CTNNB1 ELISA Kit
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96 Wells
£1042,00
OKCD07070-96WELLS
Über dieses Produkt
- SKU:
- OKCD07070
- Zusätzliche Namen:
- beta-catenin;catenin (cadherin associated protein); beta 1; 88kDa;catenin beta-1;Catnb.
- Weitere Details:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt; forms a complex with AXIN1; AXIN2; APC; CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand; CTNNB1 is not ubiquitinated and accumulates in the nucleus; where it acts as a coactivator for transcription factors of the TCF/LEF family; leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion; as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
- Gendetails:
- catenin beta 1
- Proteindetails:
- Catenin beta-1
- Empfindlichkeit:
- < 0.057ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php