CASP8 ELISA Kit
Produktgrößen
96 Wells
£788,00
OKCD06907-96WELLS
Über dieses Produkt
- SKU:
- OKCD06907
- Zusätzliche Namen:
- CASP-8;caspase-8.
- Weitere Details:
- Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3; CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3; CASP4; CASP6; CASP7; CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate; Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
- Gendetails:
- caspase 8
- Proteindetails:
- Caspase-8
- Empfindlichkeit:
- < 0.113ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php