EGFR ELISA Kit
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96 Wells
£814,00
OKCD06770-96WELLS
Über dieses Produkt
- SKU:
- OKCD06770
- Zusätzliche Namen:
- 9030024J15Rik;AI552599;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;epidermal growth factor receptor;Erb;Erbb;Err;Errb1;Errp;Wa;wa2;wa-2;Wa5;waved 2.
- Weitere Details:
- Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF; TGFA/TGF-alpha; AREG; epigen/EPGN; BTC/betacellulin; epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532).
- Gendetails:
- epidermal growth factor receptor
- Proteindetails:
- Epidermal growth factor receptor
- Empfindlichkeit:
- < 37.82pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php