CD14 ELISA Kit
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96 Wells
£814,00
OKCD06668-96WELLS
Über dieses Produkt
- SKU:
- OKCD06668
- Zusätzliche Namen:
- monocyte differentiation antigen CD14;myeloid cell-specific leucine-rich glycoprotein.
- Weitere Details:
- Coreceptor for bacterial lipopolysaccharide. In concert with LBP; binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex; thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts via MyD88; TIRAP and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response (PubMed:8612135; PubMed:15895089). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides; these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA; LprG and LpqH; in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
- Gendetails:
- CD14 antigen
- Proteindetails:
- Monocyte differentiation antigen CD14
- Empfindlichkeit:
- < 0.138ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php