FBN1 ELISA Kit
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96 Wells
£788,00
OKCD06555-96WELLS
Über dieses Produkt
- SKU:
- OKCD06555
- Zusätzliche Namen:
- ACMICD;asprosin;ECTOL1;epididymis secretory sperm binding protein;FBN;fibrillin 15;fibrillin-1;fibrillin-1 preproprotein;GPHYSD2;MASS;MFLS;MFS1;OCTD;SGS;SSKS;WMS;WMS2.
- Weitere Details:
- Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix; which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873; PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung; blood vessels and skin; microfibrils form the periphery of the elastic fiber; acting as a scaffold for the deposition of elastin. In addition; microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule; tendon; cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors; such as the bone morphogenetic proteins (BMPs); growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs); cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels; respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887; PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).
- Gendetails:
- fibrillin 1
- Proteindetails:
- Fibrillin-1
- Empfindlichkeit:
- < 0.129ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php