DARC ELISA Kit
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96 Wells
£842,00
OKCD04274-96WELLS
Über dieses Produkt
- SKU:
- OKCD04274
- Zusätzliche Namen:
- atypical chemokine receptor 1;CCBP1;CD234;DARC;DARC/ACKR1;Dfy;Duffy antigen chemokine receptor;Duffy antigen/chemokine receptor;Duffy blood group antigen;Duffy blood group system protein;Duffy blood group; chemokine receptor;FY;Fy glycoprotein;glycoprotein D;GPD;GpFy;plasmodium vivax receptor;WBCQ1.
- Weitere Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile; interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2; CCL5; CCL7; CCL11; CCL13; CCL14; CCL17; CXCL5; CXCL6; IL8/CXCL8; CXCL11; GRO; RANTES; MCP-1; TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and; consequently; leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells; it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes; serves as blood reservoir of cognate chemokines but also as a chemokine sink; buffering potential surges in plasma chemokine levels.
- Gendetails:
- atypical chemokine receptor 1 (Duffy blood group)
- Proteindetails:
- Atypical chemokine receptor 1
- Empfindlichkeit:
- 0.062 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php