GSDMD ELISA Kit
Produktgrößen
96 Wells
£901,00
OKCD04264-96WELLS
Über dieses Produkt
- SKU:
- OKCD04264
- Zusätzliche Namen:
- 1810036L03Rik;AW558049;DF5;DF5L;Dfn;Dfna5l;gasdermin domain containing 1;gasdermin domain-containing protein 1;gasdermin-D;gasderminD-1;GsdmD-1;Gsdmdc;Gsdmdc1;M2-4.
- Weitere Details:
- Gasdermin-D; N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical; as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26611636; PubMed:26375259; PubMed:26375003; PubMed:27418190; PubMed:27385778; PubMed:27383986). After cleavage; moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids; including monophosphorylated phosphatidylinositols; such as phosphatidylinositol 4-phosphate; bisphosphorylated phosphatidylinositols; such as phosphatidylinositol (4;5)-bisphosphate; as well as phosphatidylinositol (3;4;5)-trisphosphate; and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter; allowing the release of mature IL1B and triggering pyroptosis. Exhibits bactericidal activity. Gasdermin-D; N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria; without harming neighboring mammalian cells; as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity. Under cell culture conditions; also active against intracellular bacteria; such as Listeria monocytogenes. Strongly binds to bacterial and mitochondrial lipids; including cardiolipin. Does not bind to phosphatidylethanolamine or phosphatidylcholine (PubMed:27383986).
- Gendetails:
- gasdermin D
- Proteindetails:
- Gasdermin-D
- Empfindlichkeit:
- 0.063 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php