AGER Chemi-Luminescent ELISA Kit
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96 Wells
£1070,00
OKCD03285-96WELLS
Über dieses Produkt
- SKU:
- OKCD03285
- Zusätzliche Namen:
- advanced glycation end-products receptor;advanced glycosylation end product-specific receptor;RA;RAGE;receptor for advanced glycation end-products variant 20;receptor for advanced glycosylation end products.
- Weitere Details:
- Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha; oxidative stress; and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium; mononuclear phagocytes; and lymphocytes triggers cellular activation; with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling; especially stimulation of p38 mitogen-activated protein kinase (MAPK); has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation; amyloid accumulation; and impaired learning/memory in a mouse model of Alzheimer disease.
- Gendetails:
- advanced glycosylation end product-specific receptor
- Proteindetails:
- Advanced glycosylation end product-specific receptor
- Empfindlichkeit:
- 0.0137 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php