EPAS1 ELISA Kit
Produktgrößen
96 Wells
£901,00
OKCD02587-96WELLS
Über dieses Produkt
- SKU:
- OKCD02587
- Zusätzliche Namen:
- bHLHe7;bHLHe73;endothelial PAS domain-containing protein 1;EPAS-1;HIF;Hif like protein;HIF1 alpha-like factor;HIF1alpha-like factor;HIF-1-alpha-like factor;HIF-2;HIF2A;HIF2-alpha;HIF-2alpha;HIF-2-alpha;HIF-related factor;HL;HLF;HLF (HIF1alpha-like factor);HR;HRF;hypoxia inducible transcription factor 2alpha;hypoxia-inducible factor 2-alpha;mHLF;MO;MOP2.
- Weitere Details:
- Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
- Gendetails:
- endothelial PAS domain protein 1
- Proteindetails:
- Endothelial PAS domain-containing protein 1
- Empfindlichkeit:
- 0.055 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php