FGFR1 ELISA Kit
Produktgrößen
96 Wells
£901,00
OKCD02456-96WELLS
Über dieses Produkt
- SKU:
- OKCD02456
- Zusätzliche Namen:
- basic fibroblast growth factor receptor 1;bFGF-R;bFGF-R-1;c-fgr;FGF receptor-1;FGFR-1;fibroblast growth factor receptor 1;MFR;proto-oncogene c-Fgr.
- Weitere Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development; cell proliferation; differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development; normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1; FRS2; GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1; STAT1 and PTPN11/SHP2. In the nucleus; enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF; and by FGFR1 ubiquitination; internalization and degradation (By similarity).
- Gendetails:
- Fibroblast growth factor receptor 1
- Proteindetails:
- Fibroblast growth factor receptor 1
- Empfindlichkeit:
- 0.121 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php