BRCA2 ELISA Kit
Produktgrößen
96 Wells
£842,00
OKCD02407-96WELLS
Über dieses Produkt
- SKU:
- OKCD02407
- Zusätzliche Namen:
- breast cancer type 2 susceptibility protein homolog;Fanc;Fancd1;fanconi anemia group D1 protein homolog;RAB1;RAB163.
- Weitere Details:
- Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA; enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA; and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1; regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1; and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability; independently of its known role in homologous recombination (By similarity).
- Gendetails:
- breast cancer 2; early onset
- Proteindetails:
- Breast cancer type 2 susceptibility protein homolog
- Empfindlichkeit:
- 0.055 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php