GSDMD ELISA Kit
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96 Wells
£868,00
OKCD01821-96WELLS
Über dieses Produkt
- SKU:
- OKCD01821
- Zusätzliche Namen:
- DF5L;DFNA5L;FKSG10;gasdermin domain containing 1;gasdermin domain-containing protein 1;gasdermin-D;GSDMDC1.
- Weitere Details:
- Gasdermin-D; N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical; as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003; PubMed:26375259; PubMed:27418190). After cleavage; moves to the plasma membrane where it strongly binds to inner leaflet lipids; including monophosphorylated phosphatidylinositols; such as phosphatidylinositol 4-phosphate; bisphosphorylated phosphatidylinositols; such as phosphatidylinositol (4;5)-bisphosphate; as well as phosphatidylinositol (3;4;5)-bisphosphate; and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter; possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190; PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D; N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria; without harming neighboring mammalian cells; as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions; also active against intracellular bacteria; such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids; including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol; phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).
- Gendetails:
- gasdermin D
- Proteindetails:
- Gasdermin-D
- Empfindlichkeit:
- < 0.116 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php