GDF6 ELISA Kit
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96 Wells
£868,00
OKCD01632-96WELLS
Über dieses Produkt
- SKU:
- OKCD01632
- Zusätzliche Namen:
- BMP13;BMP-13;bone morphogenetic protein 13;CDMP2;growth/differentiation factor 16;growth/differentiation factor 6;KFM;KFS;KFS1;KFSL;SGM1;SYNS4.
- Weitere Details:
- Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs; skull; digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A; BMPR1B; BMPR2 and ACVR2A; leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A; BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).
- Gendetails:
- growth differentiation factor 6
- Proteindetails:
- Growth/differentiation factor 6
- Empfindlichkeit:
- < 0.059 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php