EXOSC2 ELISA Kit
Produktgrößen
96 Wells
£868,00
OKCD00550-96WELLS
Über dieses Produkt
- SKU:
- OKCD00550
- Zusätzliche Namen:
- exosome complex component RRP4;exosome complex exonuclease RRP4;Exosome component 2;homolog of yeast RRP4 (ribosomal RNA processing 4); 3' 5' exoribonuclease (RRP4);homolog of yeast RRP4 (ribosomal RNA processing 4); 3'-5'-exoribonuclease;hRrp4p;p7;ribosomal RNA-processing protein 4;RRP4;Rrp4p;SHRF.
- Weitere Details:
- Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus; the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA; snRNA and snoRNA; in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts; such as antisense RNA species and promoter-upstream transcripts (PROMPTs); and of mRNAs with processing defects; thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm; the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions; and in RNA surveillance pathways; preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis; and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
- Gendetails:
- exosome component 2
- Proteindetails:
- Exosome complex component RRP4
- Empfindlichkeit:
- < 0.057 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:html_datasheet.php