CXCL12 ELISA Kit
Produktgrößen
96 Wells
£962,00
OKCA00828-96WELLS
Über dieses Produkt
- SKU:
- OKCA00828
- Zusätzliche Namen:
- IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
- Weitere Details:
- Chemoattractant active on T-lymphocytes; monocytes; but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3; which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors; CXCR4 and ACKR3; and decreases monocyte adherence to surfaces coated with ICAM-1; a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis; myelopoiesis in bone marrow and heart ventricular septum formation.
- Gendetails:
- C-X-C motif chemokine ligand 12
- Proteindetails:
- Stromal cell-derived factor 1
- Empfindlichkeit:
- 7.81 pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store as indicated in product manual.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs