Fgfr4 ELISA Kit
Produktgrößen
96 wells/kit; with removable strips.
£1096,00
OKBB01451-96WELLS
Über dieses Produkt
- SKU:
- OKBB01451
- Zusätzliche Namen:
- Fibroblast growth factor receptor 4; FGFR-4; Protein-tyrosine kinase receptor MPK-11; CD334; Fgfr4; Fgfr-4; Mpk-11
- Weitere Details:
- Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. It is mapped to 13 B1; 13 29.8 cM. FGFR4 has also been designated as CD334 (cluster of differentiation 334). The protein encoded by this gene is a member of the fibroblast growth factor receptor family; where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. The genomic organization of this gene; compared to members 1-3; encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed; there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms; as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and; although its specific function is unknown; it is overexpressed in gynecological tumor samples; suggesting a role in breast and ovarian tumorigenesis.
- Gendetails:
- fibroblast growth factor receptor 4
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: Leu19-Asp366
- Proteindetails:
- Fibroblast growth factor receptor 4
- Empfindlichkeit:
- <50 pg/ml
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs