ELANE ELISA Kit
Produktgrößen
96 wells/kit; with removable strips.
£766,00
OKBB01431-96WELLS
Über dieses Produkt
- SKU:
- OKBB01431
- Zusätzliche Namen:
- Neutrophil elastase; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastase; ELANE; ELA2
- Weitere Details:
- In humans; neutrophil elastase is encoded by the ELANE gene; which resides on chromosome 19. It is mapped to 19p13.3. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation; this protease hydrolyzes proteins within specialized neutrophil lysosomes; called azurophil granules; as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella; Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
- Gendetails:
- elastase; neutrophil expressed
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: I30-H267
- Proteindetails:
- Neutrophil elastase
- Empfindlichkeit:
- <50 pg/ml
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs