B4GALT1 ELISA Kit
Produktgrößen
96 wells/kit; with removable strips.
£1096,00
OKBB01288-96WELLS
Über dieses Produkt
- SKU:
- OKBB01288
- Zusätzliche Namen:
- Beta-1; 4-galactosyltransferase 1; Beta-1; 4-GalTase 1; Beta4Gal-T1; beta-GlcNAc beta-1; 4-galactosyltransferase 1; beta-N-acetylglucosamine beta-1; 4-galactosyltransferase 1;
- Weitere Details:
- Beta-1;4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene. It is mapped to 9p21.1. This gene is one of seven beta-1;4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1;4 linkage to similar acceptor sugars: GlcNAc; Glc; and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins; they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity; the beta4GalTs form four groups: beta4GalT1 and beta4GalT2; beta4GalT3 and beta4GalT4; beta4GalT5 and beta4GalT6; and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity; the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts; which differ only at the 5' end; with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound; trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
- Gendetails:
- beta-1;4-galactosyltransferase 1
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: G44-S398
- Proteindetails:
- Beta-1;4-galactosyltransferase 1
- Empfindlichkeit:
- <50 pg/ml
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs