ANXA1 ELISA Kit
Produktgrößen
96 wells/kit; with removable strips.
£766,00
OKBB01211-96WELLS
Über dieses Produkt
- SKU:
- OKBB01211
- Zusätzliche Namen:
- Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35; ANXA1; ANX1; LPC1
- Weitere Details:
- ANXA1; also known as lipocortin I or Annexin A1; is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35;000 to 40;000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa; with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel; endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.
- Gendetails:
- annexin A1
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: A2-N346
- Proteindetails:
- Annexin A1
- Empfindlichkeit:
- <100 pg/ml
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs