GPNMB/Osteoactivin ELISA Kit
Produktgrößen
96 wells/kit; with removable strips.
£766,00
OKBB00561-96WELLS
Über dieses Produkt
- SKU:
- OKBB00561
- Zusätzliche Namen:
- Gpnmb; GPNMB_HUMAN; Transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB
- Weitere Details:
- Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. In osteoblast progenitor cells; GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture; demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly; GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process; possibly by promoting the fusion of osteoclast progenitor cells.
- Gendetails:
- glycoprotein (transmembrane) nmb
- Immunogen:
- Expression system for standard: NS0; Immunogen sequence: K23-P486
- Proteindetails:
- Transmembrane glycoprotein NMB
- Empfindlichkeit:
- <10 pg/ml
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4C for 6 months; at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
- Hersteller:
- Aviva Systems Biology
- Typ:
- Assay Kits: ELISAs