DUSP3 Antibody - C-terminal region
Produktgrößen
100ul
£359,00
OASG07534-100UL
Über dieses Produkt
- SKU:
- OASG07534
- Zusätzliche Namen:
- VHR
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK; SAPK/JNK; p38); which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases; different tissue distribution and subcellular localization; and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues; mutation screening in breast cancer pedigrees and in sporadic tumors was negative; leading to the conclusion that this gene is not BRCA1.
- Gendetails:
- dual specificity phosphatase 3
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the C-terminal region of human VHR.
- Isotyp:
- IgG
- Molekulargewicht:
- 21 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php