EIF2AK3 Antibody
Produktgrößen
100ul
£359,00
OASG05793-100UL
Über dieses Produkt
- SKU:
- OASG05793
- Zusätzliche Namen:
- PEK; WRS; PERK
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor; leading to a reduced overall utilization of amino acids; or to a translation initiation activator of specific mRNAs; such as the transcriptional activator ATF4; and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. ATP + a protein = ADP + a phosphoprotein. Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization; resulting in transautophosphorylation and kinase activity induction.
- Gendetails:
- eukaryotic translation initiation factor 2-alpha kinase 3
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human PERK around the phosphorylation site of T981. Location: 920-1000aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 125 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php