CBFB Antibody - N-terminal region
Produktgrößen
100ul
£359,00
OASG05780-100UL
Über dieses Produkt
- SKU:
- OASG05780
- Zusätzliche Namen:
- PEBP2B
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1; RUNX2; and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3'; or very rarely; 5'-TGCGGT-3'; within their regulatory regions via their runt domain; while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters; including murine leukemia virus; polyomavirus enhancer; T-cell receptor enhancers; LCK; IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
- Gendetails:
- core-binding factor; beta subunit
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human PEBP2Beta. Location: 30-110aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 22 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php