CDKN1A Antibody
Produktgrößen
100ul
£359,00
OASG05487-100UL
Über dieses Produkt
- SKU:
- OASG05487
- Zusätzliche Namen:
- P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- p21 is a protein encoded by the CDKN1A gene which is approximately 18;1 kDa. p21 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6; RET signalling; cyclins and cell cycle regulation. It may be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. It binds to and inhibits cyclin-dependent kinase activity; preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. It also functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. Mutations in the CDKN1A gene may result in pancreatic cancer and ovarian cancer.
- Gendetails:
- cyclin-dependent kinase inhibitor 1A (p21; Cip1)
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human p21 around the non-phosphorylation site of T145. Location: 80-160aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 21 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php