ERBB2 Antibody - middle region
Produktgrößen
100ul
£359,00
OASG04917-100UL
Über dieses Produkt
- SKU:
- OASG04917
- Zusätzliche Namen:
- NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However; it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer; stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways; such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported; with the most common allele; Ile654/Ile655; shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers; including breast and ovarian tumors. Alternative splicing results in several additional transcript variants; some encoding different isoforms and others that have not been fully characterized.
- Gendetails:
- erb-b2 receptor tyrosine kinase 2
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human Neu. Location: 610-690aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 138 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php