ERBB2 Antibody
Produktgrößen
100ul
£359,00
OASG04912-100UL
Über dieses Produkt
- SKU:
- OASG04912
- Zusätzliche Namen:
- NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Protein tyrosine kinase that is part of several cell surface receptor complexes; but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex; although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation; the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2; allowing its association with the cell membrane. In turn; membrane-bound APC allows the localization of MACF1 to the cell membrane; which is required for microtubule capture and stabilization. ; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
- Gendetails:
- erb-b2 receptor tyrosine kinase 2
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Neu around the phosphorylation site of T686. Location: 630-710aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 150 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php