DUSP1 Antibody
Produktgrößen
100ul
£359,00
OASG04554-100UL
Über dieses Produkt
- SKU:
- OASG04554
- Zusätzliche Namen:
- HVH1; MKP1; CL100; MKP-1; PTPN10
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family; and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity; and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore; it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus; DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
- Gendetails:
- dual specificity phosphatase 1
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human MKP-1/2 around the phosphorylation site of S296/318. Location: 230-310aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 45 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php