ACO1 Antibody
Produktgrößen
100ul
£359,00
OASG03967-100UL
Über dieses Produkt
- SKU:
- OASG03967
- Zusätzliche Namen:
- IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene is a bifunctional; cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high; this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low; the protein binds to iron-responsive elements (IREs); which are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE; it results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
- Gendetails:
- aconitase 1; soluble
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human IRP-1 around the phosphorylation site of S138. Location: 80-160aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 85 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php