GRIA2 Antibody
Produktgrößen
100ul
£359,00
OASG03060-100UL
Über dieses Produkt
- SKU:
- OASG03060
- Zusätzliche Namen:
- GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA); and function as ligand-activated cation channels. These channels are assembled from 4 related subunits; GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain; which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function; and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing; resulting in transcript variants encoding different isoforms; (including the flip and flop isoforms that vary in their signal transduction properties); has been noted for this gene.
- Gendetails:
- glutamate receptor; ionotropic; AMPA 2
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human GluR-2 around the non-phosphorylation site of S880. Location: 820-900aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 99 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php