FGFR4 Antibody
Produktgrößen
100ul
£359,00
OASG02707-100UL
Über dieses Produkt
- SKU:
- OASG02707
- Zusätzliche Namen:
- TKF; JTK2; CD334
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family; where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. The genomic organization of this gene; compared to members 1-3; encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed; there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms; as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and; although its specific function is unknown; it is overexpressed in gynecological tumor samples; suggesting a role in breast and ovarian tumorigenesis.
- Gendetails:
- fibroblast growth factor receptor 4
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human FGFR-4 around the phosphorylation site of Y642. Location: 580-660aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 90 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php