FEN1 Antibody - middle region
Produktgrößen
100ul
£359,00
OASG02680-100UL
Über dieses Produkt
- SKU:
- OASG02680
- Zusätzliche Namen:
- MF1; RAD2; FEN-1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate; thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore; secondary structure can deter the protective function of this protein; leading to site-specific trinucleotide expansions.
- Gendetails:
- flap structure-specific endonuclease 1
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human FEN-1. Location: 60-140aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 42 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php