F13B Antibody - N-terminal region
Produktgrößen
100ul
£359,00
OASG02623-100UL
Über dieses Produkt
- SKU:
- OASG02623
- Zusätzliche Namen:
- FXIIIB
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function; and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits; which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion; the plasma factor XIII dissociates its B subunits and yields the same active enzyme; factor XIIIa; as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules; thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency; characterized by the lack of both the A and B subunits; and type II deficiency; characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency; defective wound healing; and habitual abortion.
- Gendetails:
- coagulation factor XIII; B polypeptide
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human Factor XIII B. Location: 30-110aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 76 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php