E2F4 Antibody
Produktgrößen
100ul
£359,00
OASG02280-100UL
Über dieses Produkt
- SKU:
- OASG02280
- Zusätzliche Namen:
- E2F-4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain; a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP); a transactivation domain enriched in acidic amino acids; and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB; p107 and p130; but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes; and its gene mutation and increased expression may be associated with human cancer.
- Gendetails:
- E2F transcription factor 4; p107/p130-binding
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the human E2F-4 around the acetylation site of K96.
- Isotyp:
- IgG
- Molekulargewicht:
- 43 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php