CYP4A11 Antibody - middle region
Produktgrößen
100ul
£359,00
OASG02007-100UL
Über dieses Produkt
- SKU:
- OASG02007
- Zusätzliche Namen:
- CP4Y; CYP4A2; CYP4AII; CYPIVA11
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically; uses molecular oxygen inserting one oxygen atom into a substrate; and reducing the second into a water molecule; with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids; the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z;12Z)-octadecadienoic > hexadecanoic acid. Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver. Participates in omega-hydroxylation of (5Z;8Z;11Z;14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE); a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency. May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid; by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid; thereby initiating chain shortening. Omega-hydroxylates (9R;10S)-epoxy-octadecanoate stereoisomer. Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids. Has little activity toward prostaglandins A1 and E1.
- Gendetails:
- cytochrome P450; family 4; subfamily A; polypeptide 11
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human CYP4A11/22. Location: 360-440aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 60 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php