CCND2 Antibody
Produktgrößen
100ul
£359,00
OASG01937-100UL
Über dieses Produkt
- SKU:
- OASG01937
- Zusätzliche Namen:
- MPPH3; KIAK0002
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3; phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex; cyclin D2/CDK4/CDKN1B; required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Gendetails:
- cyclin D2
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Cyclin D2 around the non-phosphorylation site of T280. Location: 220-300aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 42 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php